Trigun takes place in the distant future on a desert planet. Vash the Stampede is a gunfighter with a legend so ruthless he has a $$60,000,000,000 bounty on his head. Entire towns evacuate at the rumor of his arrival. But the real Vash the Stampede, the enigmatic and conflicted lead character, is more heroic, even though he usually acts like a complete idiot.
Masane Amaha and her daughter Rihoko are on the run from a government child welfare agency that wants to take Rihoko away from her mother. They are caught and Rihoko is taken away. Meanwhile, Masane is attacked by an advanced weapon that can disguise itself as a human being. When faced with the danger, a strange light emits from her wrist and she transforms into a powerful being. She becomes involved in a power struggle between powerful organizations, with her at the center of their attention because she holds the greatest power of them all, the legendary Witchblade.
On a terraformed post-disaster Mars, a group of child security agents rebel against the adults who betrayed them and the oppressive Earth government.
