Following some trauma in her past that has since been repressed, a young woman is trying to recover her memories with the help of a psychiatrist. During her hypnosis sessions, she repeats the name "Tomie" but is unable to recall where she knows it from. Meanwhile, a police detective is investigating a string of brutal murders, where he also runs across the name "Tomie." How are the two connected?
Ambitious yakuza Kenji befriends harmonica-playing bartender Chuji, who moonlights as a part-time drug-dealer for the opposing gang. Their friendship is threatened by Kenji's plans for advancement, as well as by his bodyguards growing jealousy of Chuji.
Infected with Tomie's blood, a surgeon disappears, leaving his daughter, Yumi, to try to discover Tomie's identity and to solve the mystery of her father's disappearance.
