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After Port Royal is attacked and pillaged by a mysterious pirate crew, capturing the governor's daughter Elizabeth Swann in the process, William Turner asks free-willing pirate Jack Sparrow to help him locate the crew's ship—The Black Pearl—so that he can rescue the woman he loves.
When a mysterious woman seduces Dom into the world of crime and a betrayal of those closest to him, the crew face trials that will test them as never before.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.