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Set in the future, the story follows a young soldier named Johnny Rico and his exploits in the Mobile Infantry. Rico's military career progresses from recruit to non-commissioned officer and finally to officer against the backdrop of an interstellar war between mankind and an arachnoid species known as "the Bugs."
After a Soviet space station crashes into a New York City subway tunnel, a species of venomous spiders is discovered, and soon they mutate to gigantic proportions and wreak havoc on the city.
A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.
Rev. Bradford seeks the health resort conducted by William Muldoon. "Kid Garvey," who has known Mr. Muldoon for many years, calls on his old friend. Rev. Bradford arrives and he chooses the "Kid" as his trainer, believing him to be one of the regular trainers of the institution. Garvey seeks an opportunity of breaking into "swell society" and requests that he be introduced by his right name, Frank Sheldon.
