After fighting his demons for decades, John Rambo now lives in peace on his family ranch in Arizona, but his rest is interrupted when Gabriela, the granddaughter of his housekeeper María, disappears after crossing the border into Mexico to meet her biological father. Rambo, who has become a true father figure for Gabriela over the years, undertakes a desperate and dangerous journey to find her.
In their new overseas home, an American family soon finds themselves caught in the middle of a coup, and they frantically look for a safe escape in an environment where foreigners are being immediately executed.
Two tigers are separated as cubs and taken into captivity, only to be reunited years later as enemies by an explorer (Pearce) who inadvertently forces them to fight each other.
