The story follows General George Armstrong Custer's adventures from his West Point days to his death. He defies orders during the Civil War, trains the 7th Cavalry, appeases Chief Crazy Horse and later engages in bloody battle with the Sioux nation.
Arriving at Medicine Bow, eastern schoolteacher Molly Woods meets two cowboys, irresponsible Steve and the "Virginian," who gets off on the wrong foot with her. To add to his troubles, the Virginian finds that his old pal Steve is mixed up with black-hatted Trampas and his rustlers...then finds himself at the head of a posse after said rustlers; and Molly hates the violent side of frontier life.
On America's frontier, a St. Louis woman marries a New Mexico cattleman who is seen as a tyrant by the locals.
