A murder in 1944 draws together the great poets of the beat generation: Allen Ginsberg, Jack Kerouac and William Burroughs.
When brash Texas border officer Mike Norton wrongfully kills and buries the friend and ranch hand of Pete Perkins, the latter is reminded of a promise he made to bury his friend, Melquiades Estrada, in his Mexican home town. He kidnaps Norton and exhumes Estrada's corpse, and the odd caravan sets out on horseback for Mexico.
Flight attendant Cassandra Bowden wakes in her hotel room hungover from the night before in Dubai with a dead body lying next to her. Afraid to call the police, she continues her morning as if nothing happened. In New York, she is met by FBI agents who question her about her recent layover in Bangkok. Still unable to piece the night together, she begins to wonder if she could be the killer.
