An American nurse living and working in Tokyo is exposed to a mysterious supernatural curse, one that locks a person in a powerful rage before claiming their life and spreading to another victim.
Blind traveler Zatoichi is a master swordsman and a masseur with a fondness for gambling on dice games. When he arrives in a village torn apart by warring gangs, he sets out to protect the townspeople.
Hyakkimaru, a warrior on a quest to reclaim 48 of his body parts which were each taken by a demon, is joined by Dororo, a thief on a quest to avenge the death of her parents.