4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.
Damien Thorn is dead, but his prophecy is reborn in a mysterious girl named Delia, who is adopted by two attorneys.
The adventures of Joanna Beauchamp and her two adult daughters Freya and Ingrid -- both of whom unknowingly are their family's next generation of witches -- who lead seemingly quiet, uneventful modern day lives in Long Island's secluded seaside town of East Haven. When Freya becomes engaged to a young, wealthy newcomer, a series of events forces Joanna to admit to her daughters they are, in fact, powerful and immortal witches.
