After ratting out his Mafia cohorts, Giovanni Manzoni and his family enter the Witness Protection Program and relocate to a sleepy town in France. Despite the best efforts of their handler to keep them in line, Giovanni (now called Fred Blake), his wife and children can't help but resort to doing things the "family" way. However, their dependence on such old habits places everyone in danger from vengeful mobsters.
A nationwide manhunt for Hank Venture leads to untold dangers and unexpected revelations, while The Monarch is literally out for Dr Venture's blood. An imposing evil from the past reemerges to wreak havoc on the Ventures, The Guild, and even the Monarch marriage—it will take friends and foes alike to restore the Ventures' world to order… or end it once and for all.
Hank and Dean Venture, with their father Doctor Venture and faithful bodyguard Brock Samson, go on wild adventures facing megalomaniacs, zombies, and suspicious ninjas, all for the glory of adventure. Or something like that.