Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.
Deputy Marshal Sam McCloud of the small western town of Taos, New Mexico is assigned to the metropolitan New York City Police Department (NYPD) as a special investigator.
At night the Mangler stalks the streets of Los Angeles, killing and mutilating random victims. On the trail are a TV reporter, the father of one of the victims, and a police detective, but despite their efforts only the mysterious psychic DeRenzy knows what the killer is and how to stop it.
