Tod Lubitch is born with a deficient immune system. As such, he must spend the rest of his life in a completely sterile environment. His room is completely hermetically sealed against bacteria and virus, his food is specially prepared, and his only human contact comes in the form of gloved hands. The movie follows his life into a teenager.
A group of teenage girls forms a club, The Sweater Girls, to preserve their virginity.
Zeb Macahan, a pioneering westerner, helps move his brother's family to the wild west. They run into several obstacles including the breakout of the Civil War. This sends the father back to fight in the war and leaves the family to move on ahead.
