In the 1820s, a frontiersman, Hugh Glass, sets out on a path of vengeance against those who left him for dead after a bear mauling.
Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker's scheme to exterminate all mutants.
When a cure is found to treat mutations, lines are drawn amongst the X-Men—led by Professor Charles Xavier—and the Brotherhood, a band of powerful mutants organised under Xavier's former ally, Magneto.