Ray Tango and Gabriel Cash are two successful narcotics detectives who can't stand each other. Crime lord Yves Perret, furious at the loss of income they have caused him, plots an elaborate revenge against them.
A television reporter and her cameraman are trapped inside a building quarantined by the CDC after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.
Advertising executive Nick Beame learns that his wife is sleeping with his employer. In a state of despair, he encounters a bumbling thief whose attempted carjacking goes awry when Nick takes him on an involuntary joyride. Soon the betrayed businessman and the incompetent crook strike up a partnership and develop a robbery-revenge scheme. But it turns out that some other criminals in the area don't appreciate the competition.
