While recording sound effects for a slasher flick, Jack Terry stumbles upon a real-life horror: a car careening off a bridge and into a river. Jack jumps into the water and fishes out Sally from the car, but the other passenger is already dead — a governor intending to run for president. As Jack does some investigating of his tapes, and starts a perilous romance with Sally, he enters a tangled web of conspiracy that might leave him dead.
After losing an acting role and his girlfriend, Jake Scully finally catches a break: he gets offered a gig house-sitting in the Hollywood Hills. While peering through the beautiful home's telescope one night, he spies a gorgeous woman dancing in her window. But when he witnesses the girl's murder, it leads Scully through the netherworld of the adult entertainment industry on a search for answers—with porn actress Holly Body as his guide.
Investigating the mysterious deaths of a number of farm animals, vet Rack Hansen discovers that his town lies in the path of hordes of migrating tarantulas. Before he can take action, the streets are overrun by killer spiders, trapping a small group of townsfolk in a remote hotel.
