A teacher from New York moves to a small town in Texas, gets fired for being gay, and returns disguised in drag to get revenge on the people who were nasty to him.
A group of trannies are violently bashed and left for dead. The surviving ladies regain consciousness, confidence, and courage ready to seek out revenge on the ones who attacked them.
A miracle pill intended to save the world causes unforeseen side-effects forcing the surviving gays and bible thumpers in a small Texas town to join forces or fall prey to the flesh craving mutants.