Günter and Gudrun Piesold are very busy with their careers as a TV comedian and an actress, so Grandma takes care of household chores and childcare. But when Grandma remarries, the Piesolds are faced with chaos at home and a burning question: Who will take care of the household?
Berlin landlady Mrs. Klucke looks after the residents of Florentiner Strasse 73 like a mother, who could do with her help. When pregnant Brigitte is looking for a furnished room, she ends up with Mrs. Klucke. However, she has to make do with a spare room. At first Brigitte is quite disappointed that all sorts of residents and their guests regularly pass through the room, but over time she gets used to this situation. She soon comes to love the idiosyncrasies of the other residents of Florentine 73 and the motherly care of her landlady.
Brigitte is caught between two men: on the one hand there is the ambitious Klaus, the father of her young daughter, and on the other the sensitive Wolfgang, her flatmate, to whom she feels attracted. With the active help of the housemates, especially her mother Klucke, she finds out who her heart really beats for.
