Two tough Kentucky mountaineers join a trading expedition from St. Louis up the Missouri River to trade whisky for furs with the Blackfoot Indians. They soon discover that there is much more than the elements to contend with.
An evil alien brain, bent on world domination, takes over the body of an atomic scientist, while a "good" alien brain inhabits the body of the scientist's dog and waits for an opportunity to defeat the evil brain.
During the Civil War, President Abraham Lincoln sends an emissary with a peace treaty to the Sioux Indians. He also sends a gift of $130,000 in gold. This attracts the attention of Brock Marsh, the secret leader of a Confederate spy ring, who wants to keep the treaty from being signed and to also get his hands on the gold. Ruth Lawrence and Mike Daugherty work together against the machinations of Marsh
