A test rocket carrying wasps to outer space, to study the effects on them of weightlessness and radiations, crashes out of control back to Earth, into the jungles of Africa. The two astrobiologists in charge of the test mount an expedition to the Darkest Continent to retrieve their experiment, only to find the wasps have grown to giant size which are panicking all forms of life as they quest for food.
A lawyer tries to exact justice on a woman he defended in court -- a woman whom he found out was guilty after getting her off.
William Shatner plays two roles: cowboy Johnny Moon and his ruthless Indian twin brother, Notah. Notah likes peyote and gets the crazy idea that he's the Comanche messiah sent to lead the Comanche nation against the white man but more specifically the dusty desert town of Rio Hondo. Moon, estranged from his brother, decides to stop Notah either by words or by bullets.
