Pat Riley, an obnoxious busybody of indeterminable sex, meets and falls in love with Chris, a sensitive, caring person also of indeterminable sex. Their relationship suffers because Pat's a lout, and cannot decide on a direction for their life. Meanwhile, Pat's neighbor Kyle falls further and further into obsession with Pat, fascinated by their indeterminate sexuality.
Martha Horgan is a withdrawn, mentally disabled woman who lives with her aunt, Frances. One of Martha's unusual traits is that she doesn't lie, a quality that leads to her getting fired from a dry-cleaning shop thanks to the actions of the shifty Getso. Conflict seems to follow Martha, since she also becomes romantically involved with local fix-it man, Mackey, who is sleeping with Frances as well.
In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.
