One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.
Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman, Orlean's book, become strangely intertwined as each one's search for passion collides with the others'.
Determined to learn about her boyfriend's past relationships, Stacy -- who works for a talk show -- becomes a bona fide snoop. With her colleague, Barb, Stacy gets the names of Derek's ex-lovers and interviews them, supposedly for an upcoming show. But what she learns only adds to her confusion, and her plans begin to unravel when she befriends one of the women.
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