A young, idealist American gets a job as a train conductor for the Zentropa railway network in postwar, US-occupied Frankfurt. As various people try to take advantage of him, he soon finds his position politically sensitive, and gets caught up in a whirlpool of conspiracies and Nazi sympathisers.
Set in the neurosurgical ward of Copenhagen's Rigshospitalet, the city and country's main hospital, nicknamed "Riget", a number of characters, staff and patients alike, encounter bizarre phenomena, both human and supernatural.
Fisher, an ex-detective, decides to take one final case when a mysterious serial killer claims the lives of several young girls. Fisher, unable to find the culprit, turns to Osbourne, a writer who was once respected for his contributions to the field of criminology. Fisher begins to use Osbourne's technique, which involves empathizing with serial killers; however, as the detective becomes increasingly engrossed in this method, things take a disturbing turn.
