4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.
The sleepy Pacific Northwest town of Eureka is hiding a mysterious secret. The government has been relocating the world's geniuses and their families to this rustic town for years where innovation and chaos have lived hand in hand. U.S. Marshal Jack Carter stumbles upon this odd town after wrecking his car and becoming stranded there. When the denizens of the town unleash an unknown scientific creation, Carter jumps in to try to restore order and consequently learns of one of the country's best kept secrets.
Allison Dubois works in the District Attorney’s office using her natural intuition about people and her ability to communicate with the dead to help to solve crimes. Her dreams often give her clues to the whereabouts of missing people.
