For Miranda Wells, moving to New York to live in Dragonwyck Manor with her rich cousin, Nicholas, seems like a dream. However, the situation gradually becomes nightmarish. She observes Nicholas' troubled relationship with his tenant farmers, as well as with his daughter, to whom Miranda serves as governess. Her relationship with Nicholas intensifies after his wife dies, but his mental imbalance threatens any hope of happiness.
When composer George Harvey Bone wakes with no memory of the previous night and a bloody knife in his pocket, he worries that he has committed a crime. On the advice of Dr. Middleton, Bone agrees to relax, going to a music performance by singer Netta Longdon. Riveted by Netta, Bone agrees to write songs for her rather than his own concerto. However, Bone soon grows jealous of Netta and worries about controlling himself during his spells.
Poor physics student Marie is studying at the Sorbonne in 1890s Paris. One of the few women studying in her field, Marie encounters skepticism concerning her abilities, but is eventually offered a research placement in Pierre Curie's lab. The scientists soon fall in love and embark on a shared quest to extract, from a particular type of rock, a new chemical element they have named radium. However, their research puts them on the brink of professional failure.
