Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger's syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race.
When his love interest doesn't show up for a meeting, a man and his friends go to Goa in order to find her, where they discover she loves someone else.
On the eve of Nikhil and Karishma’s engagement, Karishma’s wealthy father, Devesh Solanki, expresses his disapproval, believing Nikhil to be a lackadaisical young man. With one week to prove himself worthy to marry Karishma, Nikhil and Karishma's sister, Meeta, grow closer to each other.
