A petty criminal fakes insanity to serve his sentence in a mental ward rather than prison. He soon finds himself as a leader to the other patients—and an enemy to the cruel, domineering nurse who runs the ward.
After her younger sister gets involved in drugs and is severely injured by contaminated heroin, a nurse sets out on a mission of vengeance and vigilante justice, killing drug dealers, pimps, and mobsters who cross her path.
A federal agent whose daughter dies of a heroin overdose is determined to destroy the drug ring that supplied her. He recruits various people whose lives have been torn apart by the drug trade and trains them. Then they all leave for France to track down and destroy the ring.