The most dangerous former operative of the CIA is drawn out of hiding to uncover hidden truths about his past.
Manhattan drag queens Vida Boheme and Noxeema Jackson impress regional judges in competition, securing berths in the Nationals in Los Angeles. When the two meet pathetic drag novice Chi-Chi Rodriguez — one of the losers that evening — the charmed Vida and Noxeema agree to take the hopeless youngster under their joined wing. Soon the three set off on a madcap road trip across America and struggle to make it to Los Angeles in time.
Shortly after a chemical weapon explosion in the Nevada desert, two scientists find themselves confronting a sinister cover up, and a band of hostile survivors who are looking to escape the quarantined area known as Territory 8.