A university researcher is fired because of the cuts to university. To earn a living he decides to produce drugs recruiting his former colleagues, who despite their skills are living at the margins of society.
A gangster known as "Samurai" wants to turn the waterfront of Rome into a new Las Vegas. All the local mob bosses have agreed to work for this common goal. But peace is not to last long.
Pietro Zinni is asked by the police to revive the old gang to create a task force that will stop the spread of smart drugs.