A woman in the midst of an unpleasant divorce moves to an eerie apartment building with her young daughter. The ceiling of their apartment has a dark and active leak.
In the immense city of Tokyo, the darkness of the afterlife lures some of its inhabitants who are desperately trying to escape the sadness and isolation of the modern world.
Hyakkimaru, a warrior on a quest to reclaim 48 of his body parts which were each taken by a demon, is joined by Dororo, a thief on a quest to avenge the death of her parents.