Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Mulder and Scully are called back to duty by the FBI when a former priest claims to be receiving psychic visions pertaining to a kidnapped agent.
More than seven years after the world has become a frozen wasteland, the remnants of humanity inhabit a gigantic, perpetually-moving train that circles the globe as class warfare, social injustice and the politics of survival play out.