A group of people find themselves trapped in the backwoods of West Virginia, fighting for their lives against a group of vicious and horribly disfigured inbred cannibals.
Jake Kimble, the sole survivor of the Chicago massacre, is killed while in solitary confinement. His doctor begins investigating the claims he made about a long-haired woman in white, as a mysterious Japanese woman arrives at his old apartment building to help them get rid of the curse.
Mysterious cell phone messages promise a young American engineer untold wealth - then make him the target of a deadly international plot. Dangerous security operatives chase the engineer across the globe, while a powerful government official pursues a mysterious agenda that threatens the stability of the entire world.
