When disc jockey Grant Mazzy reports to his basement radio station in the Canadian town of Pontypool, he thinks it's just another day at work. But when he hears reports of a virus that turns people into zombies, Mazzy barricades himself in the radio booth and tries to figure out a way to warn his listeners about the virus and its unlikely mode of transmission.
A submarine crew, a feared pack of forest bandits, a famous surgeon, and a battalion of child soldiers all get more than they bargained for as they wend their way toward progressive ideas on life and love.
Sailors in repose on an island paradise seemingly have no worries of war or danger — until a playful gesture is interpreted as an act of wilful aggression. Soon, the innocent act of slight slapping becomes a relentless and unforgiving orgy of open-palmed face-smacking.
