Eight people embark on an expedition into the Congo, a mysterious expanse of unexplored Africa where human greed and the laws of nature have gone berserk. When the thrill-seekers -- some with ulterior motives -- stumble across a race of killer apes.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Rescuers try to reach plane crash victims that are trapped on an isolated Mexican island populated by mutant baboons. Ron Perlman stars as a troubled guide hired to lead the mission.
