In the 1950s, a horror-comic artist's creations come alive and kill him. Years later a new cartoonist revives the creatures in his house, now part of an artist's colony.
The citizens of Comet Valley are being taken over by seeds from an alien plant that has taken root there. A sheriff investigates the strange goings-on.
Detective Sam Dietz is paired with a shady FBI agent to track down another serial killer terrorizing Los Angeles.