As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.
Depression-era bank robber John Dillinger's charm and audacity endear him to much of America's downtrodden public, but he's also a thorn in the side of J. Edgar Hoover and the fledgling FBI. Desperate to capture the elusive outlaw, Hoover makes Dillinger his first Public Enemy Number One and assigns his top agent, Melvin Purvis, the task of bringing him in dead or alive.
Due to a genetic disorder, handsome librarian Henry DeTamble involuntarily zips through time, appearing at various moments in the life of his true love, the beautiful artist Clare Abshire.
