In the depression, Chaney, a strong silent streetfighter, joins with Speed, a promoter of no-holds-barred street boxing bouts. They go to New Orleans where Speed borrows money to set up fights for Chaney, but Speed gambles away any winnings.
In this strange western version of Moby Dick, Wild Bill Hickok hunts a white buffalo he has seen in a dream. Hickok moves through a variety of uniquely authentic western locations - dim, filthy, makeshift taverns; freezing, slaughterhouse-like frontier towns and beautifully desolate high country - before improbably teaming up with a young Crazy Horse to pursue the creature.
A dabbler-in-crime and his assistant hire an ex-police reporter to recover some stolen papers.
