Dexter, a boy-genius with a secret laboratory, constantly battles his sister Dee Dee, who always gains access despite his best efforts to keep her out, as well as his arch-rival and neighbor, Mandark.
Follows the surreal adventures of a cow, named Cow, and her chicken brother, named Chicken. They are often antagonized by "The Red Guy", who poses as various characters to scam them.
The lives of two dogs, the overly excited Little Dog (the dachshund) and easy-paced Big Dog (the sheepdog). These crazy canines don't know how to fit in the world, and they definitely don't have any know-how. No matter the situation, their stupidity usually leads them to calamitous results.