A woman and her brother fly to New Guinea to look for a lost expedition, led by her husband, which has vanished in the great jungle.
Bruno Fioretti, known as "Mandrake", is an inveterate gambler who never misses a day at the horse racing track in Rome. He is doubly unlucky: he bets too much on one horse, and his wife is sleeping with his best friend because Mandrake is always at the track. Penniless and cuckolded, Mandrake decides to make one last bet.
Intrepid photojournalist Emanuelle arrives in San Francisco, where she briefly meets up with fellow journalist -- and fellow feminist -- Cora Norman, before being whisked off to India to investigate a guru con artist.
