4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.
After her own daughter abandons her child, an ambitious and orderly publisher has little choice but to raise the grandchild as her own.
In 1970s New York, Martin (Maguire) hopes to locate his father and possibly reunite the parents who have been bitterly separated since he was born.
