Chaos reigns at the natural history museum when night watchman Larry Daley accidentally stirs up an ancient curse, awakening Attila the Hun, an army of gladiators, a Tyrannosaurus rex and other exhibits.
When a cure is found to treat mutations, lines are drawn amongst the X-Men—led by Professor Charles Xavier—and the Brotherhood, a band of powerful mutants organised under Xavier's former ally, Magneto.
A group of teens journey to a remote cabin in the woods where their fate is unknowingly controlled by technicians as part of a worldwide conspiracy where all horror movie clichés are revealed to be part of an elaborate sacrifice ritual.