Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.
After his girlfriend, Julie, and two best friends are killed in a tragic auto accident, Nick struggles to cope with his loss and grief. Suffering from migraine-like seizures, Nick soon discovers that he has the power to change the past via his memories. However, his time-traveling attempts to alter the past and save his one true love have unexpected and dire consequences.
Teenager Deacon works at a video shop, and his buddies, Fred and Matt, sell the bootleg porno films he acquires. Deacon gets fired, but the pals have the bright idea of filming their own Internet porn flick in order to make money and become more popular at school. Hijinks ensue as they cast and create their movie, but porn industry player Vic Ramalot grows jealous of their burgeoning success and tries to put a stop to the project.
