An outcast half-wolf risks his life to prevent a deadly epidemic from ravaging Nome, Alaska.
Three children are accidentally transformed into fish after consuming a potion made by an eccentric scientist. The kids end up in the sea, with one problem: they must find and drink the antidote within 48 hours, or forever remain as fish.
When the Rugrats find themselves stranded on a deserted island, they meet the Thornberrys, a family who agrees to help them escape.
