Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
A series of hideous murders is taking place, and Inspector Capell and cop-turned-novelist Lonergan are investigating. The murders are found to be the work of an out-of-control experiment in genetic engineering. The two men must descend into the city's sewer systems to destroy the horrific miscreation. It won't be hard to find, as it's already looking for its next victims...
In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.