Two high school girls wander off during a class trip to the White House and meet President Richard Nixon. They become the official dog walkers for Nixon's dog Checkers, and become his secret advisors during the Watergate scandal.
Scatterbrained Polly gets a job as a secretary in Gabrielle's art gallery. Polly aspires to be a professional photographer, and idolizes Gabrielle for her artistic ability. When Gabrielle rekindles an old romantic relationship with the younger painter Mary, Polly becomes jealous, and discovers Gabrielle isn’t exactly who she claims to be.
The ghost of "patient zero", who allegedly first brought AIDS to North America - materialises and tries to contact old friends. Meanwhile, the Victorian explorer Sir Richard Burton, who drank from the Fountain of Youth and now works as Chief Taxidermist at the Toronto Natural history Museum, is trying to organise an exhibition about the disease for the museum's "Hall of Contagion".
