In 1879, the British suffer a great loss at the Battle of Isandlwana due to incompetent leadership.
Ex-DEA agent Jack receives an emergency message from his brother Phillip, whose team was ambushed on the Caribbean island of St. Keith. Jack goes to St. Keith to find his brother, who has been turned into a cyborg by the drug runner he was after.
An adventurer (Hamilton) decides to go in search of the Lost City in the Amazon jungle. A motley crew of other people decide to join him for the wealth of the city, for reasons of their own. But to their horror they find out that they have bitten off more than they can chew, what with a Nazi doctor still using the place for his human experiments.
