Joe Weber is an anthropologist who takes his son on a trip to the New England town of Salem's Lot unaware that it is populated by vampires. When the inhabitants reveal their secret, they ask Joe to write a bible for them.
Innocent people are brutally killed on the streets of New York by a uniformed police officer. A young cop, Jack Forrest, finds himself marked as the chief suspect after his wife is murdered.
A publishing executive is visited and bitten by a vampire and starts exhibiting erratic behavior. He pushes his secretary to extremes as he tries to come to terms with his affliction.