Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal" German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off.
A dying Doctor, who plans to check out on his own terms, takes a reluctant detour when he inadvertently winds up on the lam with an 'anything-but-normal' 22-year-old girl.
Former police officer Darby Spencer and her mystery novelist mother Victoria Spencer have opposite personalities but still embark on the unlikeliest of ventures: becoming partners in a private detective agency. They are mistaken as sisters as they tackle puzzling cases in Alder Bluffs.