It has been nine years since we last met Jesse and Celine, the French-American couple who once met on a train in Vienna. They now live in Paris with twin daughters but have spent a summer in Greece at the invitation of an author colleague of Jesse's. When the vacation is over and Jesse must send his teenage son off to the States, he begins to question his life decisions, and his relationship with Celine is at risk.
Following the death of their patriarch Gus, the Portokalos family travels to Greece for a family reunion, and to deliver Gus' journal to his old friends.
Four men meet in a coffee bar, where they discuss their views on life, love, and the opposite sex. As their conversation progresses, they realise they have far more in common with each other than they anticipated.