In Istanbul, retired CIA operative Bryan Mills and his wife are taken hostage by the father of a kidnapper Mills killed while rescuing his daughter.
After waking up in a hospital with amnesia, professor Robert Langdon and a doctor must race against time to foil a deadly global plot.
Special agent Orson Fortune and his team of operatives recruit one of Hollywood's biggest movie stars to help them on an undercover mission when the sale of a deadly new weapons technology threatens to disrupt the world order.