Glenn Manning, "The Amazing Colossal Man," believed dead after falling from the Hoover Dam, reemerges in rural Mexico, brain damaged, disfigured, and very angry.
Ships disappear on route across the Arctic Sea, and a special submarine is sent to investigate.
A test pilot is missing and a search party is sent out in the jungles of Mexico; however, while searching they uncover a monster in the jungle who became this way due to a dose of radioactivity.